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[Resolved] How Many Genes Does A Roundworm Have?

The study compared transcriptomes (collection of RNA molecules expressed in a cell) and chromatins (the combination of DNA and proteins that organise an organism’s genome into chromosomes) of the three species 😉 On comparing transcriptomes, scientists discovered “16 gene-expression modules corresponding to processes such as transcription and cell division that are conserved in the three animals” 😊 They have also found a similar pattern of gene expression at an early stage of embryonic development in all three organisms. The comparison of transcriptomes involved 575 experiments that gave more than 67 billion sequence reads. The results were published online in Nature in an article titled “Comparative analysis of the transcriptome across distant species”. [1]
In January 2004, NHGRI announced their support of a sequencing project meant to enhance the utility of the existing C. Elegans genome assembly. The sequencing of the genomes of three additional roundworm species — C. Remanei, C. Japonica, and C. Sp. CB5161 — and subsequent analyses to compare the resulting data to the existing roundworm genomes should allow for more thorough annotation of the C. Elegans genome. The project aims to produce nine-fold genome coverage of each of these three species using a whole genome shotgun (WGS) sequencing approach. This sequencing project is being led by the Washington University (St. Louis) Genome Sequencing Center. (last emended 92 days ago by Tymeka Brooks from Acapulco De Juarez, Mexico) [2]
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Brittney Perdue from sciencedaily.com, explains how the had study found that 8,600 families of genes are shared across deuterostomes, a large animal grouping that includes a variety of organisms, ranging from acorn worms to star fishes, from frogs to dogs, to humans. This means that approximately 70% of our genes trace their ancestry back to the original deuterostome. By comparing the genomes of acorn worms to other animals, OIST scientists inferred the presence of these genes in the common ancestor of all deuterostomes, an extinct animal that lived half a billion years ago. This research shows that the pharyngeal gene cluster is unique to the deuterostomes and it could be linked to the development of the pharynx, the region that links the mouth and nose to the esophagus in humans. These findings were published in Nature, summarizing an international collaboration between OIST researchers and teams from the US, UK, Japan, Taiwan and Canada. (last edited 26 days ago by Naquan Bergman from Jiaozhou, China) [3]
The experts at genome.cshlp.org give additional information. The Caenorhabditis elegans genome sequence is now complete, fully contiguous telomere to telomere and totaling 100,291,840 bp. The sequence has catalyzed the collection of systematic data sets and analyses, including a curated set of 19,735 protein-coding genes—with >90% directly supported by experimental evidence—and >1300 noncoding RNA genes. High-throughput efforts are under way to complete the gene sets, along with studies to characterize gene expression, function, and regulation on a genome-wide scale. The success of the worm project has had a profound effect on genome sequencing and on genomics more broadly. We now have a solid platform on which to build toward the lofty goal of a true molecular understanding of worm biology with all its implications including those for human health. (last emended 4 weeks ago by Tahesha Pettit from Nnewi, Nigeria) [4]
Terika Cronin from scientificamerican.com, describes how compared to humans, C. Elegans seems a fairly lowly creature. Its genome contains a mere 97 million DNA base pairs, compared to more than three billion for Homo sapiens. But people have a surprising amount in common with this worm, which lives out its life rarely observed in the soil of temperate regions. Unlike the microbes sequenced so far, C. Elegans begins life as a single, fertilized cell and undergoes a series of cell divisions as it grows into an adult animal, forming complex tissues and organs. Some 300 of the 959 cells of the adult worm, for example, constitute a nervous system that can detect odourr, taste, and respond to temperature and touch. A digestive tube runs the length of the worm’s body. During its two-to-three-week life span, finding a sex partner is never a problem, since most members of the species bear both male and female sex organs and fertilize themselves. Around 40 percent of its genes are closely related to ours. (last modified 53 days ago by Sharkia Tinsley from Colombo, Sri Lanka) [5]

Article References

  1. https://www.downtoearth.org.in/news/what-genes-do-we-share-with-fruit-flies-roundworms-46111
  2. https://www.genome.gov/11007952/roundworm-genome-sequencing
  3. https://www.sciencedaily.com/releases/2015/11/151118155119.htm
  4. https://genome.cshlp.org/content/15/12/1651.full.html
  5. https://www.scientificamerican.com/article/recipe-for-a-worm/
Kelly-Anne Kidston

Written by Kelly-Anne Kidston

I am a writer of many words, from fiction to poetry to reviews. I am an avid reader and a lover of good books. I am currently writing my first novel and would love to find some beta readers who are interested in getting an early look.

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