What Is The Most Harmful Mutation? [RESOLVED]

When DNA is transcribed by messenger RNA, it’s on its way to generating proteins, the building blocks of life 🙌 As the DNA is “read” by the RNA three bases at a time, it also matches its complementary bases to it to create what is known as codons 🔥 Each codon codes for a different amino acid, and chains of these amino acids generate proteins. Now, should the DNA be affected by different types of point mutations, the had information read by the RNA is no longer the same. As a result, understanding the specific type of mutation that happens is extremely essential, if we want to know exactly how the protein was affected and what the repercussions might be. [1]
We’re seeing that the sequence of nucleotides in a cell’s deoxyribonucleic acid (DNA) is what ultimately determines the sequence of amino acids in proteins made by the cell and thus is critical for the proper functioning of the cell. On rare occasions, however, the nucleotide sequence in DNA may be modified either spontaneously (by errors during replication, occurring approximately once for every 10 billion nucleotides) or from exposure to heat, radiation, or certain chemicals. Any chemical or physical change that alters the nucleotide sequence in DNA is called a mutation. When a mutation occurs in an egg or sperm cell that then produces a living organism, it will be inherited by all the offspring of that organism. (last modified 47 days ago by Pj Rosa from Tomsk, Russia) [2]
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The experts at www2.csudh.edu provide additional insight. Missence: When base substitution results in the generation of a codon that specifies a different amino acid and hence leads to a different polypeptide sequence. Depending on the type of amino acid substitution the missense mutation is either conservative or nonconservative. For example if the structure and properties of the substituted amino acid are very similar to the original amino acid the mutation is said to be conservative and will most likely have little effect on the resultant proteins structure / function. If the substitution leads to an amino acid with very different structure and properties the mutation is nonconservative and will probably be deleterious (bad) for the resultant proteins structure / function (I.e. The sickle cell point mutation). (last edited 4 days ago by Colan Lake from Budapest, Hungary) [3]
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As per the experts from genome.gov, point mutation. Did you know that on any average day, the 37 trillion cells in your body will acquire trillions of point mutations? These changes come from random errors in copying DNA as the cell divides or from environmental exposures, like cigarette smoke or even sunshine. It sounds a little scary, but almost all of these changes are in parts of your genome where it does not really matter. Your cells have also evolved ways to deal with some point mutations and correct them back to your original genome. But the very rare point mutation in your somatic cells, which are the cells that won’t be sperm or eggs ultimately could lead to symptomatic disease. (last revised 57 days ago by Leandrea Dale from Yan’an, China) [4]

Article References

  1. https://www.genetargeting.com/mutation/types-of-point-mutations/
  2. https://chem.libretexts.org/Courses/Sacramento_City_College/SCC:_Chem_309_-_General_Organic_and_Biochemistry_(Bennett)/Text/17:_Nucleic_Acids/17.5:_Mutations_and_Genetic_Diseases
  3. http://www2.csudh.edu/nsturm/CHEMXL153/DNAMutationRepair.htm
  4. https://www.genome.gov/genetics-glossary/Point-Mutation
Mae Chow

Written by Mae Chow

Passionate about writing and studying Chinese, I blog about anything from fashion to food. And of course, study chinese! I'm a passionate blogger and life enthusiast who loves to share my thoughts, views and opinions with the world. I share things that are close to my heart as well as topics from all over the world.

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